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So, even though vitamin B12 is water-soluble (meaning your body typically excretes excess through urine), extremely high levels may occasionally lead to side effects, including: Headaches or dizziness Digestive issues, such as diarrhea Skin reactions like itching or rashes Allergic reactions (rare but very serious) To avoid this, it's important to consult with a healthcare professional to determine the correct vitamin B12 dosage for your needs